| Top 15 Major Causes of Death, 2016 |
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Age-adjusted death rate (1) |
| Rank |
Cause of death |
Number of deaths |
Rate |
Percent change from 2015 |
| 1 |
Heart disease |
635,260 |
165.5 |
β1.8% |
| 2 |
Malignant neoplasms (tumors) |
598,038 |
155.8 |
β1.7 |
| 3 |
Accidents (unintentional injuries) |
161,374 |
47.4 |
9.7 |
| 4 |
Chronic lower respiratory diseases |
154,596 |
40.6 |
β2.4 |
| 5 |
Cerebrovascular diseases (stroke) |
142,142 |
37.3 |
β0.8 |
| 6 |
Alzheimer's disease |
116,103 |
30.3 |
3.1 |
| 7 |
Diabetes |
80,058 |
21.0 |
β1.4 |
| 8 |
Influenza and pneumonia |
51,537 |
13.5 |
β11.2 |
| 9 |
Kidney disease |
50,046 |
13.1 |
β2.2 |
| 10 |
Intentional self-harm (suicide) |
44,965 |
13.5 |
1.5 |
| 11 |
Septicemia |
40,613 |
10.7 |
β2.7 |
| 12 |
Chronic liver disease and cirrhosis |
40,545 |
10.7 |
β0.9 |
| 13 |
Hypertension (2) |
33,246 |
8.6 |
1.2 |
| 14 |
Parkinson's disease |
29,697 |
8.0 |
3.9 |
| 15 |
Pneumonitis due to solids and liquids |
19,715 |
5.2 |
β1.9 |
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All other causes |
546,313 |
NA |
NA |
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All deaths |
2,744,248 |
728.8 |
β0.6% |
(1) Per 100,000 population; factors out differences based on age.
(2) Essential (primary) hypertension and hypertensive renal disease.
NA=Not applicable.
Source: National Center for Health Statistics. |
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