| Top 15 Major Causes of Death, 2018 |
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Age-adjusted death rate (1) |
| Rank |
Cause of death |
Number of
deaths |
Rate |
Percent change
from 2017 |
| 1 |
Heart disease |
655,381 |
163.6 |
-0.8% |
| 2 |
Malignant neoplasms (tumors) |
599,274 |
149.1 |
-2.2 |
| 3 |
Accidents (unintentional injuries) |
167,127 |
48.0 |
-2.8 |
| 4 |
Chronic lower respiratory diseases |
159,486 |
39.7 |
-2.9 |
| 5 |
Cerebrovascular diseases (stroke) |
147,810 |
37.1 |
-1.3 |
| 6 |
Alzheimer's disease |
122,019 |
30.5 |
-1.6 |
| 7 |
Diabetes |
84,946 |
21.4 |
-0.5 |
| 8 |
Influenza and pneumonia |
59,120 |
14.9 |
4.2 |
| 9 |
Kidney disease |
51,386 |
12.9 |
-0.8 |
| 10 |
Intentional self-harm (suicide) |
48,344 |
14.2 |
1.4 |
| 11 |
Chronic liver disease and cirrhosis |
42,838 |
11.1 |
1.8 |
| 12 |
Septicemia |
40,718 |
10.2 |
-3.8 |
| 13 |
Hypertension (2) |
35,835 |
8.9 |
-1.1 |
| 14 |
Parkinson disease |
33,829 |
8.7 |
3.6 |
| 15 |
Pneumonitis due to solids and liquids |
19,239 |
4.8 |
-5.9 |
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All other causes |
571,853 |
NA |
NA |
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All deaths |
2,839,205 |
723.6 |
-1.1% |
(1) Per 100,000 population; factors out differences based on age.
(2) Essential (primary) hypertension and hypertensive renal disease.
NA=Not applicable.
Source: National Center for Health Statistics. |
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