| Top 10 Leading Causes Of Death, 2021 |
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| Rank (1) |
Cause of death |
Number of deaths |
Rate (2) |
| 1 |
Heart disease |
695,547 |
173.8 |
| 2 |
Malignant neoplasms (cancer) |
605,213 |
146.6 |
| 3 |
COVID-19 |
416,893 |
104.1 |
| 4 |
Accidents (unintentional injuries) |
224,935 |
64.7 |
| 5 |
Cerebrovascular diseases (stroke) |
162,890 |
41.1 |
| 6 |
Chronic lower respiratory diseases |
142,342 |
34.7 |
| 7 |
Alzheimer's disease |
119,399 |
31.0 |
| 8 |
Diabetes |
103,294 |
25.4 |
| 9 |
Chronic liver disease and cirrhosis |
56,585 |
14.5 |
| 10 |
Kidney disease |
54,358 |
13.6 |
| |
All other causes |
882,775 |
25.5 |
| |
All deaths |
3,464,231 |
879.7 |
(1) Based on number of deaths.
(2) Deaths per 100,000 U.S. standard population.
Source: National Center for Health Statistics, National Vital Statistics System, Mortality. |
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