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Top 10 States By Drug Poisoning Deaths And Death Rates, 2021 (1)

  By number of deaths   By deaths per 100,000 people
Rank State Number of  of deaths Deaths per 100,000 people (2) Rank State Number of  of deaths Deaths per 100,000 people
1 California 10,901 26.6 1 West Virginia 1,501 90.9
2 Florida 7,827 37.5 2 District of Columbia 3,813 56.6
3 New York 5,842 28.7 3 Kentucky 2,463 55.9
4 Pennsylvania 5,449 43.2 4 Delaware 2,381 55.6
5 Ohio 5,397 48.1 5 Ohio 513 54.0
6 Texas 4,984 16.8 6 Tennessee 1,052 51.6
7 North Carolina 3,981 39.2 7 Maryland 5,397 48.1
8 Tennessee 3,813 56.6 8 Louisana 611 47.1
9 Illinois 3,762 29.0 9 Pennsylvania 5,449 43.2
10 Michigan 3,089 31.5 10 Maine 2,811 43.0
(1) Drug overdose caused by prescription and illegal drugs. Source: Centers for Disease Control and Prevention, National Center for Health Services.